Packages containing 8 and 16 tablets. Bottle containing 60 ml
Capsules: Containers of 30 and 60 capsules. Cream: Packages containing 30 g.
Coated tablets: packages containing l5 coated tablets.
For injection: package containing 5 ampoules.
Granules x 200 mg: containers with 20 packs. Granules x 600 mg: containers with 10 and 20 packs.
Syrup: granules to prepare 100 ml.
PELMEC 5 (Amlodipine Besilate)
LOPLAC-D 50 (Losartan Potassium/Hydrochlorothiazide)
Treatment of blood hypertension when more than two active ingredients are required for satisfactory control.
Dosage and Administration
Usual Dose: 5 mg amlodipine, 12.5 mg hydrochlorothiazide, and 50 mg losartan (1 Pelmec 5 tablet and one Loplac-D tablet).
Maximum Dose: According to the therapeutic response and the physician’s judgment, this dose may be doubled (maximum Pelmec dose 10 mg, Loplac-D 100 mg/25 mg).
The peak antihypertensive action is achieved gradually, usually after two weeks of treatment.
No dosage adjustments are required in case of mild to moderate renal failure (creatinine clearance > 30 mL/min) nor in patients with mild hepatic failure.
The safety and efficacy of Pelmec 5 and Loplac-D in children have not been established.
In elderly patients requiring a triple therapeutic association for blood hypertension control, the suggested dose is the usual one.
Amlodipine besilate (PELMEC) is contraindicated in patients with known hypersensitivity to dihydropyridines.
Losartan potassium/hydrochlorothiazide (LOPLAC-D): Known hypersensitivity to losartan or hydrochlorothiazide. Pregnancy and lactation. Children. Severe renal failure. Hypersensitivity to sulfonamide-derived drugs.
PELMEC MAX D: Packages containing 30 tablets of amlodipine 5 mg and 30 coated tablets of losartan potassium 50 mg and hydrochlorothiazide 12.50 mg, respectively.